Bone & Joint Center
 

 Selected Publications

 
 

2026

  • Chougule A, Zhang C, Denbow J, Vinokurov N, Gardinier J. ARHGEF3 Deletion Increase Bone Formation and Suppresses Bone Resorption in Adult Mice. J Bone Miner Res. 2026 Jun 11:zjag099

  • Espinal EE, Mazeh M, Oravec D, Yeni YN, Kasto J, Obinero C, Zhu K, Bishai SK, Muh SJ and Mahylis JM. Are There Biomechanical Differences in Repair Technique for Lesser Tuberosity Osteotomy with Stemless Total Shoulder Arthroplasty?, JSES Reviews, Reports & Techniques, 6(4):100794, 2026

  • Fleischer M, Newton M, Hartner S, Bush CJ, Arveschoug A, Vasileff C, Hankenson K, Baker EA, Baker KC. Acute local and systemic effects of intra-articular administration of liposomal IDO-1 following anterior cruciate ligament rupture. Biochimie. 2026. S0300-9084(26)00173-2

  • Gandhi S, Lai CS, Newton M, Hartner S, Fleischer M, Salisbury M, Gellci K, Park DK, Baker EA, Baker KC. Local RANTES/CCL5 delivery and peripheral blood mobilization of endogenous marrow-derived mesenchymal stem cells to mitigate lumbar intervertebral disc degeneration. Global Spine J. 2026. 16(2):1113-1125

  • Khandare S, Lawrence RL, Jalics A, Zauel R, Moutzouros V, Makhni EC, Muh S, Bey MJ. Longitudinal Analysis of Rotator Cuff Repair: Joint Kinematics and Clinical Outcomes. Journal of Shoulder and Elbow Surgery International 10(2):101421, 2026

  • Klag EA, Oravec D, Yeni YN, McKegg PC, North T and Charters M. How Does Changing Femoral Component Anteversion Affect Biomechanics in Cementless Total Hip Arthroplasty?, Journal of Orthopaedics, 77:23-28, 2026

  • Yadav RN, Oravec DJ, Drost J, Warner E, Flynn MJ, Divine GW, Rao SD and Yeni YN. Assessment of Vertebral Bone Quality in Women With Type 2 Diabetes Mellitus using Digital Tomosynthesis, Skeletal Radiology, 2026

  • Yeni YN, Oravec DJ, Yadav RN, Drost J, Warner E, Flynn MJ, Divine GW, Rao SD. Digital tomosynthesis derived textural and geometric measures of vertebral bone quality in postmenopausal women with primary hyperparathyroidism, Journal of Endocrinological Investigation, 49(4):879-880, 2026

 
 

2025

  • Baghel M, Wilson TG, Ormseth M, Yousif P, Alkhatib A, Meysami A, Davis J, Moutzouros V, Ali SA. Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis. Sci Rep Jul 29;15(1):27612, 2025

  • Baker KC, Fleischer M, Newton M, Galasso L, Cavinatto L, Weisz K, Hartner S, Maerz T, Lammlin L, Baker EA, Allen AA, Bedi A. Pharmacologic mobilization and chemokine-directed recruitment of marrow-derived mesenchymal stromal cells to the surgically-repaired rotator cuff. Am J Sports Med. 2025. 53(8):1806-1816

  • Chougule A, Zhang C, Denbow J, Vinokurov N, Mendez D, Vojtisek E, Gardinier J. P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice. Aging Cell. 2025 May;24(5):e14464

  • Jalics AR, Zauel R, Klochko C, Moutzouros V, Bey MJ. Supraspinatus Muscle Length in the Torn Rotator Cuff: Associations with Shoulder Strength and Tear Size. Journal of Shoulder and Elbow Surgery April 34(12):2694-2702, 2025

  • Jamshidi A, Espin-Garcia O, Wilson TG, Loveless I, Pelletier JP, Martel-Pelletier J, Ali SA. MicroRNA signature for early prediction of knee osteoarthritis structural progression using integrated machine and deep learning approaches. Osteoarthritis Cartilage Mar;33(3):330-340, 2025

  • Oravec D, Yadav RN, Cushman T, Flynn MJ, Divine GW, Rao SD and Yeni YN. Osteoporosis Screening in the Mammography Setting via Digital Wrist Tomosynthesis, Osteoporosis International, 36(7):1165-1173, 2025

  • Oravec D, Zaman R, Rao S, Chang V, Divine G and Yeni YN. Facet Joint Distance Measurement Using Digital Tomosynthesis While Standing, Journal of Biomechanics, 183:112596, 2025

  • Oravec D, Zauel R, Flynn MJ, Rao S and Yeni YN. In vivo measurement of vertebral deformation using digital tomosynthesis based digital volume correlation, Journal of Biomechanics, 189:112815, 2025

  • Roberts JB, Rockel JS, Mulders R, Capellini TD, Appleton CT, Phanstiel DH, Lories R, Geurts J, Ali SA, Bhutani N, Stone L, Cruz-Almeida Y, Jurisica I, Boer CG, Ramos YFM, Rice SJ, Kapoor M. From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis. Osteoarthr Cartil Open Sep;7(3):100621, 2025

  • Wilson TG, Baghel M, Ali SA. Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics. Osteoarthritis Cartilage Nov;33(11):1293-1299, 2025

  • Wilson TG, Baghel M, Kaur N, Datta I, Loveless I, Potla P, Mendez D, Hansen L, Baker K, Lynch TS, Moutzouros V, Davis J, Ali SA. Circulating miR-126-3p is a mechanistic biomarker for knee osteoarthritis. Nat Commun Feb 27;16(1):2021, 2025

  • Yadav RN, Oravec DJ, Cushman T, Rao SD and Yeni YN, Strength and strain distributions obtained from digital wrist tomosynthesis discriminate patients with and without a history of fragility fracture, BONE, 192:117368, 2025

  • Yadav RN, Oravec DJ, Drost J, Flynn MJ, Divine GW, Rao SD and Yeni YN. Textural and geometric measures derived from digital tomosynthesis discriminate women with and without vertebral fracture, European Journal of Radiology, 183:111925, 2025

 
 

2024

  • Chougule A, Zhang C, Vinokurov N, Mendez D, Vojtisek E, Shi C, Zhang J, Gardinier J. Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity. J Cell Biol. 2024 Nov 4;223(11):e202403005

  • Khandare S, Jalics A, Lawrence RL, Zauel R, Klochko C, Bey MJ. A Novel 3D MRI-Based Approach for Assessing Supraspinatus Muscle Length. Journal of Biomechanics 168:112110, 2024

  • Lawrence RL, Soliman S, Dalboge, Lohse, Bey MJ. Investigating the multifactorial etiology of supraspinatus tendon tears. Journal of Orthopaedic Research 42(3):578-587, 2024

  • Mantebea H, Singh A, Badar F, Abedelmessih G, Sebastian TM, Baker K, Newton M, Xia Y. Characteristics of distal femoral articular cartilage in 6 weeks posttraumatic osteoarthritis by a subcritical impact. J Orthop Res. 2024. 42(4):717-728

  • Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Thomas Appleton C, Rockel JS, Kapoor M. Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies. Osteoarthritis Cartilage Apr;32(4):385-397, 2024

  • Ramos YFM, Rice SJ, Ali SA, Pastrello C, Jurisica I, Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Thomas Appleton C, Rockel JS, Kapoor M. Evolution and advancements in genomics and epigenomics in OA research: How far we have come. Osteoarthritis Cartilage Jul;32(7):858-868, 2024

  • Singh A, Mantebea H, Badar F, Batool S, Abdelmessih G, Sebastian T, Newton M, Baker K, Salem S, Xia Y. Assessment of post-trauma microstructural alterations in the rabbit knee cartilage and subchondral bone. J Anat. 2024. 245(5):740-750

  • Singh A, Mantebea H, Badar F, Batool S, Abdelmessih G, Sebastian T, Newton M, Baker K, Salem S, Xia Y. Assessment of articular cartilage degradation in response to an impact injury using mMRI. Connect Tissue Res. 2024. 65(2):146-60

  • Sinz NJ, Hwang RW, Lee GH, Baker KC, Arnold P, Sasso R, Park D, Fischgrund J, Niu R, Kim DH. Pedicle screw-associated violation of the adjacent unfused facet joint: Clinical outcomes and fusion rates. Global Spine J. 2024. 14(5):477-84

  • Zang K, Brossard M, Wilson T, Ali SA, Espin-Garcia O. A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis. Osteoarthr Cartil Open Dec;6(4):100540, 2024

 
 

2023

  • Alizadeh AH, Lively S, Lepage S, Potla P, Russell S, Ali SA, Kapoor M, Koch TG. MicroRNAs as Prognostic Markers for Chondrogenic Differentiation Potential of Equine Mesenchymal Stromal Cells. Stem Cells Dev Nov;32(21-22):693-702, 2023

  • Chargo NJ, Schepper JD, Rios-Arce N, Kang HJ, Gardinier JD, Parameswaran N, McCabe LR. Lactobacillus Reuteri 6475 Prevents Bone Loss in a Clinically Relevant Oral Model of Glucocorticoid-Induced Osteoporosis in Male CD-1 Mice. JBMR Plus. 2023 Aug 13;7(12):e10805

  • Fleischer MM, Hartner SE, Newton MD, Baker KC, Maerz T. Early patellofemoral cartilage and bone pathology in a rat model of noninvasive anterior cruciate ligament rupture. Connect Tissue Res. 2023. 64(2):175-185

  • Gardinier JD, Chougule A, Mendez D, Daly-Seiler C, Zhang C. Periosteal Bone Formation Varies with Age in Periostin Null Mice. Calcif Tissue Int. 2023 Apr;112(4):463-471

  • Lawrence RL, Soliman SB, Roseni K, Zauel R, Bey MJ. In vivo evaluation of rotator cuff internal impingement during scapular plane abduction. Journal of Orthopaedic Research (4):718-726, 2023

  • LeRoy TE, Smith IC, Kim DH, Golenbock SW, Baker KC, Arnold PM, Sasso RC, Park DK, Fischgrund JS, Zaidi QH, Hwang RW. Clinical significance of lateral pedicle screw malposition in lumbar spine fusion. Clin Spine Surg. 2023. 36(6):E258-E262

  • Rocha FAC, Ali SA. Soluble biomarkers in osteoarthritis in 2022: year in review. Osteoarthritis Cartilage Feb;31(2):167-176, 2023

  • Wilson TG, Baghel M, Kaur N, Moutzouros V, Davis J, Ali SA. Characterization of miR-335-5p and miR-335-3p in human osteoarthritic tissues. Arthritis Res Ther Jun 16;25(1):105, 2023

  • Yadav RN, Oravec DJ, Morrison CK, Bevins NB, Rao SD and Yeni YN. Digital Wrist Tomosynthesis (DWT)-Based Finite Element Analysis of Ultra-Distal Radius Differentiates Patients With and Without a History of Osteoporotic Fracture, BONE, 177:116901, 2023

  • Yeni YN, Oravec D, Drost J, Zauel R and Flynn MJ. Stiffness and Strain Properties Derived from Digital Tomosynthesis-based Digital Volume Correlation Predict Vertebral Strength Independently from Bone Mineral Density”, Journal of Biomechanical Engineering, 145(4) / 041009:1-8, 2023

 
 

2022

  • Ali SA, Bowden JL. Editorial: Implementation of physical, psychosocial, and mind-body approaches for the management of osteoarthritis. Front Rehabil Sci 3:1023931, 2022

  • Ali SA, Espin-Garcia O, Wong AK, Potla P, Pastrello C, McIntyre M, Lively S, Jurisica I, Gandhi R, Kapoor M. Circulating microRNAs differentiate fast-progressing from slow-progressing and non-progressing knee osteoarthritis in the Osteoarthritis Initiative cohort. Ther Adv Musculoskelet Dis 14:1759720X221082917, 2022

  • Espin-Garcia O, Baghel M, Brar N, Whittaker JL, Ali SA. Can genetics guide exercise prescriptions in osteoarthritis? Front Rehabil Sci 3:930421, 2022

  • Gardinier JD, Chougule A, Zhang C. The mechanotransduction of MLO-Y4 cells is disrupted by the senescence-associated secretory phenotype of neighboring cells. J Cell Physiol. 2022 Apr;237(4):2249-2257

  • Jun BJ, Ricchetti ET, Haladik J, Bey MJ, Patterson TE, Subhas N, Li ZM, Iannotti JP. Validation of a Metal Artifact Reduction 3-D CT Imaging Method for Quantifying Implant Migration following Anatomic Total Shoulder Arthroplasty, Journal of Orthopaedic Research 0(6):1270-1280, 2022

  • Lawrence RL, Roseni K, Bey MJ. Correspondence Between Scapular Anatomical Coordinate Systems And The 3D Axis of Motion: A New Perspective On An Old Challenge. Journal of Biomechanics, 2022

  • Lawrence RL, Ruder MC, Zauel R, Jalics A, Olszewski A, Diefenbach BJ, Moutzouros V, Makhni EC, Muh S, Bey MJ. In-Vivo Static Retraction and Dynamic Elongation of Rotator Cuff Repair Tissue After Surgical Repair: A Preliminary Analysis at 3 Months. Orthopedic Journal of Sports Medicine 10(3), 2022

  • Oravec D, Kim W, Flynn MJ and Yeni YN. The Relationship of Whole Human Vertebral Body Creep to Bone Density and Texture via Clinically Available Imaging Modalities, Journal of Biomechanics, 135:111021, 2022

  • Ruder MC, Lawrence RL, Soliman SB, Zauel R, Bey MJ. Pre-Surgical Tear Characteristics and Estimated Shear Modulus as Predictors of Repair Integrity and Shoulder Function One Year After Surgical Rotator Cuff Repair, Journal of Shoulder and Elbow Surgery International 6(1):62-69, 2022

  • Ruder MC, Zauel R, Diefenbach BJ, Bey MJ. Quantifying Shoulder Activity After Rotator Cuff Repair: Technique And Preliminary Results, Journal of Orthopaedic Research 40(4):917-924, 2022

  • Tavallaee G, Lively S, Rockel JS, Ali SA, Im M, Sarda C, Mitchell GM, Rossomacha E, Nakamura S, Potla P, Gabrial S, Matelski J, Ratneswaran A, Perry K, Hinz B, Gandhi R, Jurisica I, Kapoor M. Contribution of MicroRNA-27b-3p to Synovial Fibrotic Responses in Knee Osteoarthritis. Arthritis Rheumatol Dec;74(12):1928-1942, 2022

  • Yeni YN, Azad S, Oravec D, Schildcrout A, Basheer A, Bey MJ, Bartol SW, Chang V. Intervertebral kinematics during neck motion 6.5 years after fusion and artificial disc replacement. Clinical Biomechanics, 2022

  • Yeni YN, Dix MR, Xiao A and Oravec DJ. Uniaxial compressive properties of human lumbar 1 vertebrae loaded beyond compaction and their relationship to cortical and cancellous microstructure, size and density properties, Journal of the Mechanical Behavior of Biomedical Materials, 133:105334, 2022

  • Yeni YN, Dix MR, Xiao A, Oravec DJ and Flynn MJ. Measuring the thickness of vertebral endplate and shell using digital tomosynthesis, BONE, 157:116341, 2022

 
 

2021

  • Ali SA, Lee K, MacDermid JC. Applying the International Classification of Functioning, Disability and Health to understand osteoarthritis management in urban and rural community-dwelling seniors. Osteoarthr Cartil Open Mar;3(1):100132, 2021

  • Ali SA, Pastrello C, Kaur N, Peffers MJ, Ormseth MJ, Jurisica I. A Network Biology Approach to Understanding the Tissue-Specific Roles of Non-Coding RNAs in Arthritis. Front Endocrinol (Lausanne) 12:744747, 2021

  • Ali SA, Peffers MJ, Ormseth MJ, Jurisica I, Kapoor M. The non-coding RNA interactome in joint health and disease. Nat Rev Rheumatol Nov;17(11):692-705, 2021

  • Baker EA, Fleischer MM, Vara AD, Salisbury MR, Baker KC, Fortin PT, Friedrich CR. Local and systemic in vivo responses to osseointegrative titanium nanotube surfaces. Nanomaterials. 2021. 11(3):583

  • Endisha H, Datta P, Sharma A, Nakamura S, Rossomacha E, Younan C, Ali SA, Tavallaee G, Lively S, Potla P, Shestopaloff K, Rockel JS, Krawetz R, Mahomed NN, Jurisica I, Gandhi R, Kapoor M. MicroRNA-34a-5p Promotes Joint Destruction During Osteoarthritis. Arthritis Rheumatol Mar;73(3):426-439, 2021

  • Gandhi S, Newton MD, Salisbury M, Baker KC. Technical experience and post-operative complications with repeat transperitoneal approach to the lumbar spine in female Lewis rats. Lab Animal. 2021. 55(1):81-87

  • Gardinier JD. The Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes. Curr Osteoporos Rep. 2021 Aug;19(4):436-443

  • Lawrence RL, Ruder MC, Moutzouros V, Makhni EC, Muh SJ, Siegal D, Soliman SC, van Holsbeeck M, Bey MJ. Ultrasound Shear Wave Elastography And Its Association With Rotator Cuff Tear Characteristics, Journal of Shoulder and Elbow Surgery International 5(3):500-506, 2021

  • Lawrence RL, Zauel R, Bey MJ. Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography, Journal of Visualized Experiments 169, 2021

  • Maerz T, Newton MD, Fleischer M, Hartner SE, Gawronski K, Junginger L, Baker KC. Traumatic joint injury induces acute catabolic bone turnover concurrent with articular cartilage damage in a rat model of posttraumatic osteoarthritis. J Orthop Res. 2021. 39(9):1965-1976

  • Mobasheri A, Kapoor M, Ali SA, Lang A, Madry H. The future of deep phenotyping in osteoarthritis: How can high throughput omics technologies advance our understanding of the cellular and molecular taxonomy of the disease? Osteoarthr Cartil Open Dec;3(4):100144, 2021

  • Oravec D, Drost J, Zauel R, Flynn MJ and Yeni YN. Assessment of Intravertebral Mechanical Strains and Cancellous Bone Texture Under Load using a Clinically Available Digital Tomosynthesis Modality, Journal of Biomechanical Engineering, 143 (10):101011, 2021

  • Potla P, Ali SA, Kapoor M. A bioinformatics approach to microRNA-sequencing analysis. Osteoarthr Cartil Open Mar;3(1):100131, 2021

  • Trompeter N, Gardinier JD, DeBarros V, Boggs M, Gangadharan V, Cain WJ, Hurd L, Duncan RL. Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4. Cell Calcium. 2021 Nov;99:102467

  • Wilson T, Kaur N, Davis J, Ali SA. Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint. J Vis Exp Jul 22;(173), 2021

  • Yeni YN, Oravec D, Drost J, Bevins N, Morrison C and Flynn MJ. Bone Health Assessment via Digital Wrist Tomosynthesis in the Mammography Setting, BONE 144. paper no: 115804, 2021